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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Welcome to ECOSYS

UMR ECOSYS - Ecologie fonctionnelle et écotoxicologie des agroécosystèmes

CEMABS Project


Chronic level exposure to antibiotics and metals in soils: impact on microbial processes including the dynamics of antibiotic-resistance
Durée :


Financement :



Sylvie NAzaret, CNRS, LEM, Villeurbanne.

  • INRA Pessac Versailles
  • INRA EGC Grignon
  • INRA AgroEcologie Dijon
  • LTHE Grenoble
  • Rovaltain, Drôme
Contact EGC :

Sabine Houot

Descriptif :

The intensive use of antibiotics in human and veterinary medicine led to the widespread dissemination of AB in the environment. As chemicals antibiotic exerts a selective pressure on organisms. To cope with the toxic effect of antibiotic microorganisms have evolved many strategies leading to the emergence and spread of resistance genes among a wide range of microbial species and the increase prevalence of multidrug resistance among pathogens including opportunistic ones.

Over the past decade concern has grown about the adverse effects antibiotics in the environment might potentially have on human and ecological health. However the amount and the frequency of antibiotics released into the environment strongly differ from that occurring in the highly exposed areas as are hospital and waste water treatment plants.Furthermore anthropogenic sources of antibiotics might contain several contaminants (i.e. several pharmaceuticals, metals) and can be associated to a complex organic matter that modifies contaminant properties.Similarly soils as agricultural fields might already be contaminated with various chemicals as organic pesticides and metals that regularly entry soil or have been accumulated through repeated treatments. These compounds are also known to alter microbial cell integrity and act as selective agents that can co-select for various resistances including antibiotic resistance.

The objectives of this program are to evaluate whether the joint dispersal of antibiotics and metals in soils through chronic level exposure, would impact diversity and functions of microbial communities and contributes to raise tolerance within bacterial communities and led to the emergence of new antibiotic resistance mechanisms. This will be achieved with a special emphasis on the spatial distribution of the contaminants and the microorganisms within the soil matrix and taking into account parameters that will influence bioavailability.