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Séminaire - 21 septembre

Séminaire - 21 septembre
Yohann Petit (Sainsbury Lab., Norwich Research Park, UK) : "Identification of new M. oryzae sHMA-interacting effectors"

Yohann Petit nous présentera son projet de post-doc. Son exposé s'intitulera :"Identification of new M. oryzae sHMA-interacting effectors"

Résumé : To infect its host plants and counteract plant defences, Magnaporthe oryzae deploys an arsenal of small secreted proteins collectively called effectors. Some of these effectors interact with so-called small Heavy-Metal Associated (sHMA) proteins to circumvent immunity. These effectors can also activate resistance proteins carrying integrated HMA domains. Examples include the effectors AVR-Pia and AVR1-CO39, which are recognized by the same resistance protein from the NLR (Nucleotide and Leucine-rich Repeat) superfamily, RGA5, through an integrated HMA domain. The AVR-Pik effector is also recognized by such a domain integrated in the Pik-1 resistance protein. More recently, one putative effector homolog of AVR-Pik, namely APikL2, has been shown to physically interact with sHMA proteins, presumably to circumvent plant defences. In order to find new M. oryzae effectors interacting with sHMA targets, and possibly recognized by HMA-containing NLR, we analyzed secretomes of M. oryzae isolates infecting different hosts such as rice, wheat, finger millet, foxtail millet and oat. First, we identified proteins showing sequence similarity to known M. oryzae avirulence effectors. Second, we performed a search for remote homologies based on a Hidden Markov Model (HMM) profile built after multiple sequence alignment constrained by structural alignment of M. oryzae effectors known to share a structural fold. These two approaches identified 185 potential effector candidates. We are now testing those candidates for their ability to interact with sHMA proteins. This work aims to identify new M. oryzae sHMA interacting effectors, improving our understanding of the specificity of interaction of such effectors with HMA proteins at the molecular level, and thereby allowing the design of new and improved immune receptors.

Yohann Petit1-2, Joe Win1, Thorsten Langner1, Claudia Reyes-Avila1, Sophien Kamoun1
1The Sainsbury Laboratory, Norwich Research Park, Norwich, UK
2UMR BIOGER, INRA, AgroParisTech, Université Paris-Saclay, Avenue Lucien Brétignières, BP 01, F-78850 Thiverval-Grignon, France.